I Agreed with Euphy or u can put some Delay on Skill to make sure that WPE / RPE or Macro Dont Work in ur Server ... Just Edit here
// Minimum allowed delay for ANY skills after casting (in miliseconds) (Note 1)
// Note: Setting this to anything above 0 can stop speedhacks.
min_skill_delay_limit: 200
Its Work on my last server for stop those program ... Either they use the program its still not function anymore